4-Chloro-3,5-dinitrobenzoic acid
- Name: 4-Chloro-3,5-dinitrobenzoic acid
- CAS: 118-97-8
- Purity: 99%
Details
Offer Chemical Raw Material 4-Chloro-3,5-dinitrobenzoic acid 118-97-8 In Stock
- Molecular Formula: C7H3ClN2O6
- Molecular Weight: 246.564
- Appearance/Colour: yellow crystals
- Vapor Pressure: 6.73E-08mmHg at 25°C
- Melting Point: 159-162 °C
- Refractive Index: 1.6500 (estimate)
- Boiling Point: 422.7 °C at 760 mmHg
- PKA: 2?+-.0.10(Predicted)
- Flash Point: 209.4 °C
- PSA： 128.94000
- Density: 1.791 g/cm3
- LogP: 2.90100
4-Chloro-3,5-dinitrobenzoic acid(Cas 118-97-8) Usage
|
Hazard |
irritant |
|
Synthesis |
The synthesis of?4-Chloro-3,5-dinitrobenzoic acid is as follows:4-chloro-benzoic acid? (20 g, 0.128 mol) was dissolved in H2SO4 (d = 1.835 g/mL, 300 mL) at80 C, and KNO3 (66 g, 0.65 mol) was added. The reaction mixture was heated to 125 C using ahigh-pressure flask and kept for 2 h, after which the reaction was cooled to rt and poured onto ice.The yield of 4-Chloro-3,5-dinitrobenzoic acid?was 28 g (89%) . |
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Purification Methods |
Crystallise the acid from EtOH/ H2O, EtOH or *C6H6. The 1:1 naphthalene complex (by fusing various ratios of ingredients and recrystallising from EtOH) has m 122o. [Beilstein 9 H 416, 9 III 1953, 9 IV 1360.] |
InChI:InChI=1/C7H3ClN2O6/c8-6-4(9(13)14)1-3(7(11)12)2-5(6)10(15)16/h1-2H,(H,11,12)/p-1
118-97-8 Relevant articles
Nitrocarbons. 3. Synthesis of Decanitrobiphenyl
Nielsen, Arnold T.,Norris, William P.,Atkins, Ronald L.,Vuono, William R.
, p. 1056 - 1059 (1983)
The synthesis of 4,4'-diamino-2,2',3,3',...
New protein reagents. II. 4-chloro-3,5-dinitrophenacyl bromide.
Diopoh,Olomucki
, p. 220 - 225 (1972)
-
Bio-derived CuO nanocatalyst for oxidation of aldehyde: A greener approach
Tamuly, Chandan,Saikia, Indranirekha,Hazarika, Moushumi,Das, Manash R.
, p. 20636 - 20640 (2014)
Eco-friendly synthesis of hierarchical C...
Synthesis and biological evaluation of 1,3-dideazapurine-like 7-amino-5-hydroxymethyl-benzimidazole ribonucleoside analogues as aminoacyl-tRNA synthetase inhibitors
Aerschot, Arthur Van,Gadakh, Bharat,Lescrinier, Eveline,Nautiyal, Manesh,Pang, Luping,Rozenski, Jef,Strelkov, Sergei V.,Weeks, Stephen D.,Zhang, Baole,de Graef, Steff
, (2020/10/27)
Aminoacyl-tRNA synthetases (aaRSs) have ...
A novel method to synthesize stable nitrogen-rich polynitrobenzenes with π-stacking for high-energy-density energetic materials
Yang, Xiaoming,Lin, Xinyu,Yang, Li,Zhang, Tonglai
, p. 10296 - 10299 (2018/09/21)
Two nitrogen-rich energetic compounds wi...
A 1,4-bis (2,6-dinitro-4-carboxylic acid phenoxy) benzene synthetic method (by machine translation)
-
Paragraph 0008, (2016/10/10)
The invention discloses a 1,4? Double (2...
Aromatic triazole foldamers induced by C-H...X (X = F, Cl) intramolecular hydrogen bonding
Shang, Jie,Gallagher, Nolan M.,Bie, Fusheng,Li, Qiaolian,Che, Yanke,Wang, Ying,Jiang, Hua
, p. 5134 - 5144 (2014/06/23)
Aryl-triazole oligomers based on isobuty...
118-97-8 Process route
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-
74-11-3
para-chlorobenzoic acid
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-
118-97-8
4-chloro-3,5-dinitrobenzoic acid
| Conditions | Yield |
|---|---|
|
With
sulfuric acid; sulfur trioxide; nitric acid;
1.) 25-30 deg C, 2.) 85 deg C, 3.) 95 deg C, 4.5 h;
|
89.6%
|
|
With
sulfuric acid; potassium nitrate;
at 125 ℃;
for 2h;
High pressure;
|
89%
|
|
With
sulfuric acid; potassium nitrate;
at 130 - 140 ℃;
for 1.5h;
|
82.5%
|
|
With
sulfuric acid; nitric acid;
at 135 - 140 ℃;
|
|
|
With
sulfuric acid; nitric acid;
at 70 - 100 ℃;
dann bis 140grad erhitzen;
|
|
|
With
sulfuric acid; potassium nitrate;
|
|
|
Multi-step reaction
with
6
steps
1: sulfuric acid; iodine; chromium(VI) oxide / 24 h / 25 - 30 °C
2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium(0)
; copper(l) iodide / tetrahydrofuran / 55 °C / Inert atmosphere
5: potassium fluoride dihydrate; methanol / tetrahydrofuran / 4 h / 20 °C
6: sulfuric acid; potassium nitrate / 5 h / 40 - 140 °C
With
chromium(VI) oxide; methanol; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); oxalyl dichloride; potassium fluoride dihydrate; sulfuric acid; iodine; potassium nitrate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane;
|
|
|
With
dinitrogen tetroxide; sulfuric acid;
at 90 ℃;
for 4h;
|
-
-
106-43-4
para-chlorotoluene
-
-
118-97-8
4-chloro-3,5-dinitrobenzoic acid
| Conditions | Yield |
|---|---|
|
para-chlorotoluene;
With
potassium permanganate;
In
water;
at 120 ℃;
for 1.83333h;
With
nitric acid;
In
water;
at 60 ℃;
for 0.333333h;
Temperature;
|
118-97-8 Upstream products
-
7221-27-4
4-amino-3,5-dinitrobenzoic acid
-
96-99-1
4-chloro-3-nitrobenzoate
-
74-11-3
para-chlorobenzoic acid
-
83-05-6
bis(4'-chlorophenyl)acetic acid
118-97-8 Downstream products
-
332173-27-0
3,5-dinitro-4-piperidino-benzoic acid
-
2347-38-8
4-dipropylamino-3,5-dinitrobenzoic acid
-
82366-55-0
N,N-dimethyl-4-carboxy-2,6-dinitroaniline
-
857538-47-7
4-diethylamino-3,5-dinitro-benzoic acid
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