Details
Manufacturer Supply Best Quality BENZAMIDINE 618-39-3 with Efficient Transportation
- Molecular Formula: C7H8N2
- Molecular Weight: 120.154
- Melting Point: 65-70 °C
- Boiling Point: 208.5 °C at 760 mmHg
- PKA: 11.90±0.40(Predicted)
- Flash Point: 79.9 °C
- PSA： 49.87000
- Density: 1.09 g/cm3
- LogP: 1.77070
BENZAMIDINE(Cas 618-39-3) Usage
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Chemical Description |
Benzamidine is a molecule with biological and pharmacological relevance. |
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Synthesis Reference(s) |
The Journal of Organic Chemistry, 27, p. 1255, 1962 DOI: 10.1021/jo01051a033Tetrahedron Letters, 31, p. 1969, 1990 DOI: 10.1016/S0040-4039(00)88891-7 |
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Biochem/physiol Actions |
Benzamidine is an inhibitor of plasmin and has been used in the radioimmunoassay of glucagon in human plasma. It prevents the destruction of Thyrotropin-releasing hormone (TRH) added to whole blood in vitro before radioimmunoassay of TRH. |
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Purification Methods |
It is liberated from its hydrochloride chloride (below) by treatment with 5M NaOH, extracted into diethyl ether, dried (Na2SO4) and sublimed in vacuo.[Beilstein 9 H 280, 9 I 123, 9 II 199, 9 1264, 9 IV 898.] |
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General Description |
Benzamidine is utilized as a nucleophile in a micelle-catalyzed, one-pot synthesis of biologically active benzo[a]phenazines and naphtho[2,3-d]imidazoles, demonstrating its role in facilitating regio- and chemoselective reactions under environmentally friendly aqueous conditions. |
InChI:InChI=1/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9)
618-39-3 Relevant articles
Benzamidine
Barker,Phillips,Wallbridge,Powell
, p. 2617 - 2619 (1996)
Benzenecarboximidamide, C7H8N2, has been...
NADH cytochrome b5 reductase and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans
Kurian, Joseph R.,Bajad, Sunil U.,Miller, Jackie L.,Chin, Nathaniel A.,Trepanier, Lauren A.
, p. 1171 - 1178 (2004)
Hydroxylamine metabolites, implicated in...
Assembly of 5-Aminoimidazoles via Palladium-Catalysed Double Isocyanide Insertion Reaction
Wang, Xu,Fu, Jin-Ping,Mo, Jia-Hui,Tian, Yu-Hong,Liu, Chun-You,Tang, Hai-Tao,Sun, Zi-Jun,Pan, Ying-Ming
, p. 2762 - 2766 (2021)
A palladium-catalysed tandem cyclisation...
Compounds for Treating Cannabinoid Toxicity and Acute Cannabinoid Overdose
-
, (2022/02/11)
The present invention relates to novel c...
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation
Li, Shuai,Li, Xin-Yang,Li, Yu-Heng,Lin, Qi-Qi,Liu, Kai-Li,Meng, Fan-Hao,Qian, Xin-Hua,Wang, De-Pu,Xue, Wen-Han
, p. 13356 - 13372 (2021/09/20)
Based on the novel allosteric site of de...
Toward Continuous-Flow Synthesis of Biologically Interesting Pyrazole Derivatives
Das, Amrita,Ishitani, Haruro,Kobayashi, Shū
supporting information, p. 5127 - 5132 (2019/11/13)
A two-step continuous-flow synthesis of ...
618-39-3 Process route
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930-69-8
sodium thiophenolate
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4222-25-7
3-bromo-3-phenyl-3H-diazirine
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100-47-0
benzonitrile
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618-39-3
benzamidin
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882-33-7
diphenyldisulfane
| Conditions | Yield |
|---|---|
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In
methanol;
at 25 ℃;
Rate constant;
Mechanism;
var. NaSPh conc.; also 15N-labelled phenylbromodiaziryne, other bromo- and chloro-aryldiazirines, also with sodium thioacetate;
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92%
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16118-22-2
benzylidenamine
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7664-41-7
ammonia
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potassium amide
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484-47-9
lophine
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618-39-3
benzamidin
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100-46-9
benzylamine
| Conditions | Yield |
|---|---|
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at 210 ℃;
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618-39-3 Upstream products
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44830-55-9
3-cyano-1-isopropylguanidine
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16118-22-2
benzylidenamine
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5333-86-8
ethyl benzimidate hydrochloride
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1147550-11-5
ammonium thiocyanate
618-39-3 Downstream products
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100869-87-2
2-phenyl-5,6,7,8-tetrahydroquinazoline
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1722-18-5
2-phenyl-1,3,5-triazine
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1898-74-4
2,4-diphenyl-1,3,5-triazine
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75793-17-8
2-phenyl-5-[1-furan-2-yl-meth-(Z)-ylidene]-3,5-dihydro-imidazol-4-one
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BIS(TRIMETHYLSILYL) SULFIDECAS：3385-94-2