4-chloro-2,5-diethoxyaniline

  • Name: 4-chloro-2,5-diethoxyaniline
  • CAS: 35271-60-4
  • Purity: 99%
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  • Molecular Formula: C10H14 Cl N O2
  • Molecular Weight: 215.68
  • Vapor Pressure: 0.000112mmHg at 25°C 
  • Boiling Point: 336.5°Cat760mmHg 
  • Flash Point: 157.3°C 
  • PSA： 44.48000 
  • Density: 1.167g/cm3 
  • LogP: 3.30080 

4-chloro-2,5-diethoxyaniline(Cas 35271-60-4) Usage

InChI:InChI=1/C10H14ClNO2/c1-3-13-9-6-8(12)10(14-4-2)5-7(9)11/h5-6H,3-4,12H2,1-2H3

35271-60-4 Relevant articles

Structure-activity relationship studies of 1-(4-chloro-2,5-dimethoxyphenyl) -3-(3-propoxypropyl)thiourea, a non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type-1

Weitman, Michal,Lerman, Keti,Nudelman, Abraham,Major, Dan Thomas,Hizi, Amnon,Herschhorn, Alon

experimental part, p. 447 - 467 (2011/03/20)

The reverse transcriptase (RT) of the hu...

35271-60-4 Process route

1-chloro-2,5-diethoxy-4-nitrobenzene
91-43-0

1-chloro-2,5-diethoxy-4-nitrobenzene

4-chloro-2,5-diethoxyaniline
35271-60-4

4-chloro-2,5-diethoxyaniline

Conditions
Conditions Yield
With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h;
100%
With hydrogenchloride; tin(ll) chloride;
2-chloro-1,4-diethoxybenzene
52196-74-4

2-chloro-1,4-diethoxybenzene

4-chloro-2,5-diethoxyaniline
35271-60-4

4-chloro-2,5-diethoxyaniline

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: acetic acid; aqueous HNO3
2: SnCl2 ; concentrated aqueous HCl
With hydrogenchloride; nitric acid; acetic acid; tin(ll) chloride;
Multi-step reaction with 2 steps
1: HNO3 -SiO2 / dichloromethane / Sonication
2: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C
With HNO3-SiO2; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane;

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