Details
High Quality Chinese Manufacturer supply 496-41-3 Benzofuran-2-carboxylic acid
- Molecular Formula: C9H6O3
- Molecular Weight: 162.145
- Appearance/Colour: white to light yellow crystal powder
- Vapor Pressure: 0mmHg at 25°C
- Melting Point: 193-196 °C(lit.)
- Refractive Index: 1.649
- Boiling Point: 313.379 °C at 760 mmHg
- PKA: 3.12±0.30(Predicted)
- Flash Point: 143.327 °C
- PSA： 50.44000
- Density: 1.364 g/cm3
- LogP: 2.13100
Benzofuran-2-carboxylic acid(Cas 496-41-3) Usage
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Synthesis Reference(s) |
Journal of the American Chemical Society, 73, p. 872, 1951 DOI: 10.1021/ja01146a532Organic Syntheses, Coll. Vol. 3, p. 209, 1955 |
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Purification Methods |
The acid crystallises from water. [Beilstein 18/6 V 419.] |
InChI:InChI=1/C9H6O3/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5H,(H,10,11)
496-41-3 Relevant articles
Palladium-Catalyzed C?H Functionalization of Phenyl 2-Pyridylsulfonates
Li, Bin,Guo, Dong-Dong,Guo, Shi-Huan,Pan, Gao-Fei,Gao, Ya-Ru,Wang, Yong-Qiang
, p. 130 - 144 (2017)
An efficient palladium(II)-catalyzed int...
1,4-Addition of an aryllithium reagent to diethyl ketomalonate. Scalable synthesis of ethyl 1-(hydroxymethyl)-1,3-dihydroisobenzofuran-1-carboxylate
Rocke, Benjamin N.,Conn, Edward L.,Eisenbeis, Shane A.,Ruggeri, Roger B.
, p. 5467 - 5470 (2012)
While optimizing the synthesis of pharma...
Oxidative Cleavage of β -Keto Sulfones via Nitrous Acid
Abdel-Aziz, Hatem A.
, (2014)
The reaction of nitrous acid with 1-aryl...
Synthesis and biological evaluation of a series of novel benzofuran-2-carboxylate 1,2,3-triazoles
Bhaskar, K.,Yadav, J. S.
, p. 767 - 774 (2021/09/28)
A facile and efficient synthetic route h...
Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs)
Linciano, Pasquale,Benedetti, Rosaria,Pinzi, Luca,Russo, Fabiana,Chianese, Ugo,Sorbi, Claudia,Altucci, Lucia,Rastelli, Giulio,Brasili, Livio,Franchini, Silvia
, (2020/11/24)
Histone Deacetylases (HDACs) are among t...
Synthesis and biological evaluation of novel shikonin-benzo[b]furan derivatives as tubulin polymerization inhibitors targeting the colchicine binding site
Kong, Ling-Yi,Leng, Jia-Fu,Lian, Bao-Ping,Shao, Yu-Ying,Xia, Yuan-Zheng,Yin, Yong
, (2020/02/11)
A novel series of shikonin-benzo[b]furan...
Redox-Neutral Photocatalytic C?H Carboxylation of Arenes and Styrenes with CO2
Bergonzini, Giulia,Brandt, Peter,Fricke, Florian,Johansson, Magnus J.,K?nig, Burkhard,Schmalzbauer, Matthias,Svejstrup, Thomas D.
supporting information, p. 2658 - 2672 (2020/10/07)
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496-41-3 Process route
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3199-61-9
ethyl coumarilate
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496-41-3
Benzofuran-2-carboxylic acid
| Conditions | Yield |
|---|---|
|
With
potassium hydroxide;
In
ethanol; water;
for 2h;
Reflux;
|
85%
|
|
With
potassium hydroxide;
In
ethanol;
|
82%
|
|
With
potassium hydroxide;
for 1h;
Yield given;
Heating;
|
|
|
With
sodium hydroxide;
at 20 ℃;
|
|
|
With
water; sodium hydroxide;
In
methanol;
for 0.5h;
Heating;
|
|
|
With
lithium hydroxide monohydrate;
In
tetrahydrofuran; methanol; water;
at 20 ℃;
for 18h;
|
|
|
With
sodium hydroxide;
In
water; N,N-dimethyl-formamide;
at 60 ℃;
for 0.5h;
|
|
|
With
water;
for 1h;
Reflux;
|
800 mg
|
|
ethyl coumarilate;
With
water; sodium hydroxide;
In
ethanol;
for 1h;
Heating;
With
hydrogenchloride;
In
ethanol; water;
pH=1;
|
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![1-(benzo[b]furan-2-yl)ethanone](/upload/2026/6/cf2a5524235b4926823e3a8d138d54cb_0c521a42-eefe-4503-bd4d-9017e4a6d4f3.png)
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1646-26-0
1-(benzo[b]furan-2-yl)ethanone
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496-41-3
Benzofuran-2-carboxylic acid
| Conditions | Yield |
|---|---|
|
With
Oxone; trifluoroacetic acid;
In
1,4-dioxane;
for 10h;
Reflux;
Green chemistry;
|
80%
|
|
With
potassium permanganate;
|
|
|
With
alkaline aqueous sodium hypochlorite solution;
|
496-41-3 Upstream products
-
54008-77-4
2-bromo-1-benzofuran
-
59214-70-9
3-bromobenzofuran
-
109-72-8
n-butyllithium
-
60-29-7
diethyl ether
496-41-3 Downstream products
-
1646-27-1
methyl benzofuran-2-carboxylate
-
3199-61-9
ethyl coumarilate
-
5396-02-1
3-phenyl-2,3-dihydro-benzofuran-2-carboxylic acid
-
271-89-6
1-benzofurane
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