Details
Quality Factory Supply 99% Pure 4-Bromo-3,5-dimethylpyrazole 3398-16-1 with Efficient Delivery
- Molecular Formula: C5H7 Br N2
- Molecular Weight: 175.028
- Appearance/Colour: pale white or light yellow crystal powder
- Melting Point: 119-121 ºC
- Refractive Index: 1.5500 (estimate)
- Boiling Point: 269.1 °C at 760 mmHg
- PKA: 13.83±0.50(Predicted)
- Flash Point: 116.5 °C
- PSA： 28.68000
- Density: 1.595 g/cm3
- LogP: 1.78900
4-Bromo-3,5-dimethylpyrazole(Cas 3398-16-1) Usage
InChI:InChI=1/C5H7BrN2/c1-3-5(6)4(2)8-7-3/h1-2H3,(H,7,8)
3398-16-1 Relevant articles
Tumor microenvironment and NIR laser dual-responsive release of berberine 9-: O -pyrazole alkyl derivative loaded in graphene oxide nanosheets for chemo-photothermal synergetic cancer therapy
Cai, Shundong,Du, Peifang,Liu, Yanfei,Liu, Zhenbao,Long, Shuo,Peng, Dongming,Wang, Yirong,Wen, Nachuan,Xiong, Hongjie,Yan, Jianhua
, p. 4046 - 4055 (2020)
A berberine 9-O-pyrazole alkyl derivativ...
R4NHal/NOHSO4: A Usable System for Halogenation of Isoxazoles, Pyrazoles, and beyond
Bondarenko, Oksana B.,Karetnikov, Georgy L.,Komarov, Arseniy I.,Pavlov, Aleksandr I.,Nikolaeva, Svetlana N.
supporting information, p. 322 - 332 (2021/01/14)
A new convenient and versatile halogenat...
Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS
Bencheva, Leda Ivanova,De Matteo, Marilenia,Ferrante, Luca,Ferrara, Marco,Prandi, Adolfo,Randazzo, Pietro,Ronzoni, Silvano,Sinisi, Roberta,Seneci, Pierfausto,Summa, Vincenzo,Gallo, Mariana,Veneziano, Maria,Cellucci, Antonella,Mazzocchi, Nausicaa,Menegon, Andrea,Di Fabio, Romano
supporting information, p. 627 - 632 (2019/03/07)
Acid-sensing ion channels (ASICs) are a ...
A mild halogenation of pyrazoles using sodium halide salts and Oxone
Olsen, Kathryn L.,Jensen, Matthew R.,MacKay, James A.
supporting information, p. 4111 - 4114 (2017/09/29)
A mild, inexpensive, and operationally s...
3398-16-1 Process route
-
-
67-51-6
3,5-dimethyl-1H-pyrazole
-
-
3398-16-1
4-Bromo-3,5-dimethylpyrazole
| Conditions | Yield |
|---|---|
|
With
N-Bromosuccinimide;
In
ethyl acetate;
at 25 - 30 ℃;
for 0.25h;
Sonication;
|
100%
|
|
With
N-Bromosuccinimide;
In
ethyl acetate;
at 25 - 30 ℃;
for 0.1h;
ultrasound irradiation;
|
98%
|
|
With
nitrosylsulfuric acid; nitromethane; tetramethylammonium bromide;
at 0 - 20 ℃;
for 20h;
|
95%
|
|
With
bromine chloride;
In
dichloromethane;
for 1h;
Ambient temperature;
|
94%
|
|
With
oxone; sodium bromide;
In
water;
at 20 ℃;
for 1h;
|
93%
|
|
With
bromine;
In
water;
|
64%
|
|
With
water; bromine; sodium acetate;
|
|
|
With
bromine;
In
dichloromethane;
at -78 - 0 ℃;
|
|
|
With
N-Bromosuccinimide;
In
tetrachloromethane;
for 2h;
Heating;
|
|
|
With
bromine;
In
dichloromethane;
at -78 - 20 ℃;
|
|
|
Multi-step reaction
with
2
steps
1: Br2
, 1N Na2
CO3
/ CH2
Cl2
/ 0.17 h / 0 °C
2: 8 percent / AgNO3
*P(OCH3
)3 / acetonitrile / Ambient temperature
With
bromine; sodium carbonate; silver nitrate; phosphorous acid trimethyl ester;
In
dichloromethane; acetonitrile;
|
|
|
With
N-Bromosuccinimide;
In
tetrachloromethane; dichloromethane;
|
|
|
With
N-Bromosuccinimide;
In
acetone;
at 25 - 30 ℃;
for 8h;
|
|
|
With
N-Bromosuccinimide;
In
tetrachloromethane;
|
|
|
With
N-Bromosuccinimide;
In
dichloromethane;
at 37 ℃;
for 12h;
|
-
-
51108-53-3
1-benzyl-4-bromo-3,5-dimethyl-1H-pyrazole
-
-
3398-16-1
4-Bromo-3,5-dimethylpyrazole
| Conditions | Yield |
|---|---|
|
With
potassium tert-butylate; oxygen; dimethyl sulfoxide;
at 25 ℃;
for 0.166667h;
|
82%
|
3398-16-1 Upstream products
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3398-16-1 Downstream products
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-
444177-46-2
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49764-18-3
di-(1-adamantyl) ether
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